Clinical significance of T cell receptor repertoire in primary Sjogren's syndrome.

ABSTRACT:

Background

Primary Sjogren's syndrome (SS) is a chronic inflammatory disease with unknown aetiology. Although clonal expansion of autoreactive T cells has been identified in patients with SS, the clinical correlation of T-cell receptor (TCR) variance in SS remains unclear.

Methods

TCRβ repertoire sequencing was performed on 260 SS patients with 3-6 months of follow-up in a cohort study to dynamically assess the characteristics of TCR diversity and their clinical significance.

Findings

We found that SS patients had lower TCR diversity, but higher frequency of public clones than healthy controls (HCs). Significant differences were identified in the usage of the variable (V) gene, joining (J) gene, and V-J pairing between SS and HCs. Eighteen SS-associated clones were id

SUBMITTER: Lu C 

PROVIDER: S-EPMC9471496 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature