Lep gene and leptin concentration in serum of schizophrenia patients with metabolic syndrome

ABSTRACT:

Introduction

Schizophrenia is associated with lower life expectancy due to cardiovascular disease. Metabolic syndrome (MetS) occupies an important place among the main problems. Indicators of hormones regulating metabolism may be appealing candidates as biomarkers of metabolic side-effects. Certain role belongs to genetic factors that might be the basis of sensitivity to development of MetS.

Objectives

The aim is to study polymorphisms of leptin gene (LEP) and serum leptin concentration in schizophrenia patients with metabolic syndrome.

Methods

After obtaining informed consent, patients with schizophrenia (ICD-10: F20) were included: 91 patients for biochemical research and 463 patients for genotyping. Patients were divided into two groups: 46 (119) with MetS; 45

SUBMITTER: Boiko A 

PROVIDER: S-EPMC9471844 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature