Platelet-activating factor receptor antagonists of natural origin for acute ischemic stroke: a systematic review of current evidence.

ABSTRACT: Background: Acute ischemic stroke (AIS) is a common cause of death and long-term disability worldwide. Recent trials of platelet-activating factor receptor antagonists (PAFRA) appeared to indicate that they could play a neuroprotective role in the treatment of AIS; therefore, we conducted a systematic literature review to evaluate the clinical efficacy and safety of PAFRA in patients with AIS. Methods: A systematic literature search was performed in seven electronic databases from inception to 11 March 2022. All randomized controlled trials (RCTs) in which patients were treated with PAFRA strategies within 7 days of stroke onset were included. Modified Rankin Scale (mRS) was selected as the primary outcome of this systematic review. The methodological quality of included stud

SUBMITTER: Li T 

PROVIDER: S-EPMC9471864 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature