Effect of Vitamin D3 and Omega-3 Fatty Acid Supplementation on Risk of Frailty: An Ancillary Study of a Randomized Clinical Trial.

ABSTRACT:

Importance

Preventive strategies for frailty are needed. Whether supplements with anti-inflammatory properties, such as vitamin D3 or marine omega-3 fatty acids, are useful for frailty prevention is unknown.

Objective

To test the effects of vitamin D3 and omega-3 supplements on change in frailty in older individuals.

Design, setting, and participants

This study was conducted in 2021, as a prespecified ancillary to the Vitamin D and Omega-3 (VITAL) trial, a 2 × 2 factorial randomized clinical trial. A total of 25 871 individuals (men aged ≥50 years and women aged ≥55 years), without cancer or cardiovascular disease and with data on frailty, were recruited across all 50 US states from November 2011 to March 2014 and followed up through December 31, 2017. Data analysis f

SUBMITTER: Orkaby AR 

PROVIDER: S-EPMC9471979 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature