Altered dynamic amplitude of low-frequency fluctuation between bipolar type I and type II in the depressive state.

ABSTRACT:

Background

Bipolar disorder is a chronic and highly recurrent mental disorder that can be classified as bipolar type I (BD I) and bipolar type II (BD II). BD II is sometimes taken as a milder form of BD I or even doubted as an independent subtype. However, the fact that symptoms and severity differ in patients with BD I and BD II suggests different pathophysiologies and underlying neurobiological mechanisms. In this study, we aimed to explore the shared and unique functional abnormalities between subtypes.

Methods

The dynamic amplitude of low-frequency fluctuation (dALFF) was performed to compare 31 patients with BD I, 32 with BD II, and 79 healthy controls (HCs). Global dALFF was calculated using sliding-window analysis. Group differences in dALFF among the 3 groups were co

SUBMITTER: Liu W 

PROVIDER: S-EPMC9472068 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature