Peptide emulsions in incomplete Freund's adjuvant create effective nurseries promoting egress of systemic CD4⁺ and CD8⁺ T cells for immunotherapy of cancer.

ABSTRACT: Water-in-oil emulsion incomplete Freund's adjuvant (IFA) has been used as an adjuvant in preventive and therapeutic vaccines since its development. New generation, highly purified modulations of the adjuvant, Montanide incomplete seppic adjuvant (ISA)-51 and Montanide ISA-720, were developed to reduce toxicity. Montanide adjuvants are generally considered to be safe, with adverse events largely consisting of antigen and adjuvant dose-dependent injection site reactions (ISRs). Peptide vaccines in Montanide ISA-51 or ISA-720 are capable of inducing both high antibody titers and durable effector T cell responses. However, an efficient T cell response depends on the affinity of the peptide to the presenting major histocompatibility complex class I molecule, CD4⁺ T cell help and/or t

SUBMITTER: Melssen MM 

PROVIDER: S-EPMC9472143 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature