A novel, robust method for quantification of multiple kynurenine pathway metabolites in the cerebrospinal fluid.
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ABSTRACT:
SUBMITTER: Schwieler L
PROVIDER: S-EPMC9472175 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
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A novel, robust method for quantification of multiple kynurenine pathway metabolites in the cerebrospinal fluid.
Schwieler Lilly L Trepci Ada A Krzyzanowski Stanislaw S Hermansson Sigurd S Granqvist Mathias M Piehl Fredrik F Venckunas Tomas T Brazaitis Marius M Kamandulis Sigitas S Lindqvist Daniel D Jones Arthur Daniel AD Erhardt Sophie S Brundin Lena L
Bioanalysis 20200325 6
<b>Aim:</b> Kynurenine metabolites are potential modulators of psychiatric disease. We aimed to develop a highly sensitive biochemical analysis of cerebrospinal fluid (CSF) tryptophan (TRP) metabolites, to investigate the stability of metabolites and to confirm our previous findings of aberrant CSF quinolinic acid (QUIN) and picolinic acid (PIC) in suicide attempters using this method. <b>Methodology & results:</b> Ten CSF TRP metabolites were analyzed with ultraperformance LC-MS/MS. The method ...[more]
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