Interactions between Nitric Oxide and Hyaluronan Implicate the Migration of Breast Cancer Cells.

ABSTRACT: Nitric oxide (^•NO) is one of the prominent free radicals, playing a pivotal role in breast cancer progression. Hyaluronic acid (HA) plays an essential role in neutralizing free radicals in tumor tissues. However, its interactions with nitric oxide have not been thoroughly investigated. Hence, this study attempts to understand the mechanism of these interactions and the different effects on the intracellular ^•NO levels and migration of breast cancer cells. The affinity of HA to scavenge ^•NO was investigated alongside the accompanying changes in specific physico-chemical properties and the further effects on the ^•NO-induced attachment and migration of the breast cancer cell lines, MDA-MB-231 and HCC1806. The reaction of the nitrogen dioxide radical

SUBMITTER: Alsharabasy AM 

PROVIDER: S-EPMC9472231 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature