Zn(II) and Cd(II) Complexes of AMT1/MAC1 Homologous Cys/His-Rich Domains: So Similar yet So Different.

ABSTRACT: Infections caused by Candida species are becoming seriously dangerous and difficult to cure due to their sophisticated mechanisms of resistance. The host organism defends itself from the invader, e.g., by increasing the concentration of metal ions. Therefore, there is a need to understand the overall mechanisms of metal homeostasis in Candida species. One of them is associated with AMT1, an important virulence factor derived from Candida glabrata, and another with MAC1, present in Candida albicans. Both of the proteins possess a homologous Cys/His-rich domain. In our studies, we have chosen two model peptides, L680 (Ac-₁₀ACMECVRGHRSSSCKHHE₂₇-NH₂, MAC1, Candida albicans) and L681 (Ac-₁₀ACDSCIKSHKAAQCEHNDR_28<

SUBMITTER: Rola A 

PROVIDER: S-EPMC9472267 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature