Phthalate exposure and metabolic effects: a systematic review of the human epidemiological evidence.

ABSTRACT:

Objective

We performed a systematic review of the epidemiology literature to identify the metabolic effects associated with phthalate exposure.

Data sources and study eligibility criteria

Six phthalates were included in the review: di(2‑ethylhexyl) phthalate (DEHP), diisononyl phthalate (DINP), dibutyl phthalate (DBP), diisobutyl phthalate (DIBP), butyl benzyl phthalate (BBP), and diethyl phthalate (DEP). The initial literature search (of PubMed, Web of Science, and Toxline) included all studies of metabolic effects in humans, and outcomes were selected for full systematic review based on data availability.

Study evaluation and synthesis methods

Studies of diabetes and insulin resistance were evaluated using criteria defined a priori for risk of bias and sensitivity b

SUBMITTER: Radke EG 

PROVIDER: S-EPMC9472300 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature