Construction and validation of a predictive model for hepatocellular carcinoma based on serum markers.

ABSTRACT:

Background

Early hepatocellular carcinoma (HCC) detection with non-invasive biomarkers remains an unmet clinical need. We aimed to construct a predictive model based on the pre-diagnostic levels of serum markers to predict the early-stage onset of HCC.

Methods

A total of 339 HCC patients (including 157 patients from Changzhou cohort and 182 patients from Wuxi cohort) were enrolled in our retrospective study. Levels of 25 baseline serum markers were collected. Propensity score matching (PSM) analysis was conducted to balance the distributions of patients' gender, age, and the surveillance time between HCC group and control group. Then, Receiver operating characteristic (ROC) and Logistic regression analysis were performed to screen the independent predictive variables and con

SUBMITTER: Zheng L 

PROVIDER: S-EPMC9472335 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature