Beta amyloid deposition and cognitive decline in Parkinson's disease: a study of the PPMI cohort.

ABSTRACT: The accumulation of beta amyloid in the brain has a complex and poorly understood impact on the progression of Parkinson's disease pathology and much controversy remains regarding its role, specifically in cognitive decline symptoms. Some studies have found increased beta amyloid burden is associated with worsening cognitive impairment in Parkinson's disease, especially in cases where dementia occurs, while other studies failed to replicate this finding. To better understand this relationship, we examined a cohort of 25 idiopathic Parkinson's disease patients and 30 healthy controls from the Parkinson's Progression Marker Initiative database. These participants underwent [¹⁸F]Florbetaben positron emission tomography scans to quantify beta amyloid deposition in 20 cortical region

SUBMITTER: Mihaescu AS 

PROVIDER: S-EPMC9472347 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature