Absence of long-term changes in urine biomarkers after AKI: findings from the CRIC study.

ABSTRACT:

Background

Mechanisms by which AKI leads to CKD progression remain unclear. Several urine biomarkers have been identified as independent predictors of progressive CKD. It is unknown whether AKI may result in long-term changes in these urine biomarkers, which may mediate the effect of AKI on CKD progression.

Methods

We selected 198 episodes of hospitalized AKI (defined as peak/nadir inpatient serum creatinine values ≥ 1.5) among adult participants in the Chronic Renal Insufficiency Cohort (CRIC) Study. We matched the best non-AKI hospitalization (unique patients) for each AKI hospitalization using pre-hospitalization characteristics including eGFR and urine protein/creatinine ratio. Biomarkers were measured in banked urine samples collected at annual CRIC study visits.

Res

SUBMITTER: McCoy IE 

PROVIDER: S-EPMC9472364 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature