Time course of the triglyceride glucose index accumulation with the risk of cardiovascular disease and all-cause mortality.

ABSTRACT:

Background

Future risk of cardiovascular disease (CVD) and mortality is associated with cumulative amount TyG index (cumTyG) exposure, while whether time course of TyG accumulation modulates the risk remains unclear. This study sought to examine the associations of cumTyG index accumulation time course with the risk of CVD and all-cause mortality.

Methods

We enrolled 51,734 participants free of CVD and underwent three examinations at year 2006, 2008, and 2010. CumTyG from baseline to the third examination was calculated. Time course of cumTyG accumulation was calculated as the slope of TyG versus time from 2006 to 2010, or as splinting the overall TyG index accumulation into early (cumTyG_06 - 08) and late accumulation (cumTyG_08 - 10). Participants were

SUBMITTER: Tian X 

PROVIDER: S-EPMC9472367 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature