Testing the generalizability of ancestry-specific polygenic risk scores to predict prostate cancer in sub-Saharan Africa.

ABSTRACT:

Background

Genome-wide association studies do not always replicate well across populations, limiting the generalizability of polygenic risk scores (PRS). Despite higher incidence and mortality rates of prostate cancer in men of African descent, much of what is known about cancer genetics comes from populations of European descent. To understand how well genetic predictions perform in different populations, we evaluated test characteristics of PRS from three previous studies using data from the UK Biobank and a novel dataset of 1298 prostate cancer cases and 1333 controls from Ghana, Nigeria, Senegal, and South Africa.

Results

Allele frequency differences cause predicted risks of prostate cancer to vary across populations. However, natural selection is not the primary driver

SUBMITTER: Kim MS 

PROVIDER: S-EPMC9472407 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature