Monocyte subsets display age-dependent alterations at fasting and undergo non-age-dependent changes following consumption of a meal.

ABSTRACT:

Background

Monocytes are a heterogenous population of immune cells whose subsets and functions become substantially dysregulated with advanced age. Although much of our current understanding of the age-related changes in monocytes is derived from fasting blood samples, most people are predominately in the postprandial state during waking hours. As hormonal, metabolic, and immunological changes in response to the consumption of a meal are manifested in postprandial blood, it's unclear how age-dependent changes in peripheral monocytes at fasting are impacted by a dietary challenge.

Objective

We investigated the impact of age and meal consumption on circulating monocyte frequencies and subsets defined as classical (CD14 + CD16-), intermediate (CD14 + CD16 +), or non-classical (

SUBMITTER: Snodgrass RG 

PROVIDER: S-EPMC9472410 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature