A systematic quality evaluation and review of nanomaterial genotoxicity studies: a regulatory perspective.

ABSTRACT: The number of publications in the field of nanogenotoxicology and the amount of genotoxicity data on nanomaterials (NMs) in several databases generated by European Union (EU) funded projects have increased during the last decade. In parallel, large research efforts have contributed to both our understanding of key physico-chemical (PC) parameters regarding NM characterization as well as the limitations of toxicological assays originally designed for soluble chemicals. Hence, it is becoming increasingly clear that not all of these data are reliable or relevant from the regulatory perspective. The aim of this systematic review is to investigate the extent of studies on genotoxicity of NMs that can be considered reliable and relevant by current standards and bring focus to what is needed for

SUBMITTER: Siivola KM 

PROVIDER: S-EPMC9472411 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature