Pulmonary dust foci as rat pneumoconiosis lesion induced by titanium dioxide nanoparticles in 13-week inhalation study.

ABSTRACT:

Background

Most toxicological studies on titanium dioxide (TiO₂) particles to date have concentrated on carcinogenicity and acute toxicity, with few studies focusing of pneumoconiosis, which is a variety of airspace and interstitial lung diseases caused by particle-laden macrophages. The present study examined rat pulmonary lesions associated with pneumoconiosis after inhalation exposure to TiO₂ nanoparticles (NPs).

Methods

Male and female F344 rats were exposed to 6.3, 12.5, 25, or 50 mg/m³ anatase type TiO₂ NPs for 6 h/day, 5 days/week for 13 weeks using a whole-body inhalation exposure system. After the last exposure the rats were euthanized and blood, bronchoalveolar lavage fluid, and all tissues including lungs and mediastinal

SUBMITTER: Yamano S 

PROVIDER: S-EPMC9472424 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature