Immune-mediated diseases are associated with a higher incidence of dementia: a prospective cohort study of 375,894 individuals.

ABSTRACT:

Background

Immune system dysregulation plays a vital role in the pathogenesis of neurodegenerative diseases, even considered to be as important as classical pathological protein aggregation assumption. However, the associations of immune-mediated diseases with incident dementia are unclear and need to be clarified in prospective studies with a large population and long follow-up time.

Methods

We investigated the relationship between any or individual immune-mediated diseases and incident dementia based on a prospective cohort UK Biobank. The risk for dementia was assessed with multivariable hazard ratio (HR) and 95% confidence interval (CI) after adjusting for various potential confounders using time-varying Cox proportional hazards regression. We also performed the subgroup

SUBMITTER: Zhang YR 

PROVIDER: S-EPMC9472428 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature