Adenoviral vector-based COVID-19 vaccines-associated cerebral venous sinus thromboses: Are those adverse events related to the formation of neutrophil extracellular traps? Asociacion de las vacunas frente a la COVID-19 basadas en vectores de adenovirus y trombosis del seno venoso cerebral: ¿guardan relacion estos episodios con la formacion de trampas extracelulares de neutrofilos?

ABSTRACT: In March and April 2021 several countries temporarily suspended vaccinations with adenoviral vector-based COVID-19 vaccines. Concerns of national regulators particularly regarded very rare cases of cerebral venous sinus thrombosis after immunization with this type of vaccine. Until now, these adverse events were interpreted as standard hypercoagulable events, but their clinical characteristics suggest that they may actually represent unique thrombotic disorders referred to as immunothrombosis. In this paper it is speculated that it is possible that immunothrombosis after this type of vaccine results from formation of neutrophil extracellular traps (NETs) in veins affected by stagnant blood flow. Such a stasis occurs in individuals with anatomical variants of cerebral venous outflow, which

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PROVIDER: S-EPMC9472699 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature