Characterization of genetic predisposition to molecular subtypes of breast cancer in Brazilian patients.

ABSTRACT:

Introduction

BRCA1 and BRCA2 germline pathogenic variants (GPVs) account for most of the 5-10% of breast cancer (BC) that is attributable to inherited genetic variants. BRCA1 GPVs are associated with the triple negative subtype, whereas BRCA2 GPVs are likely to result in higher grade, estrogen-receptor positive BCs. The contribution of other genes of high and moderate risk for BC has not been well defined and risk estimates to specific BC subtypes is lacking, especially for an admixed population like Brazilian.

Objective

The aim of this study is to evaluate the value of a multigene panel in detecting germline mutations in cancer-predisposing genes for Brazilian BC patients and its relation with molecular subtypes and the predominant molecular ance

SUBMITTER: Paixao D 

PROVIDER: S-EPMC9472814 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature