Multistage rocket: integrational design of a prodrug-based siRNA delivery system with sequential release for enhanced antitumor efficacy.

ABSTRACT: An integrated peptide-camptothecin prodrug (RSC) system was designed as a nano-sized multistage rocket for the efficient complexation and controlled sequential release of siRNA and anticancer drug under tumor-relevant reductive and esterase-enriched conditions, which facilitated the avoidance of negative interactions and maximized the synergistic effect.

SUBMITTER: Jiang Q 

PROVIDER: S-EPMC9473180 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature