S1P (Sphingosine-1-Phosphate)-Induced Vasodilation in Human Resistance Arterioles During Health and Disease.

ABSTRACT:

Background

Preclinical studies suggest that S1P (sphingosine-1-phosphate) influences blood pressure regulation primarily through NO-induced vasodilation. Because microvascular tone significantly contributes to mean arterial pressure, the mechanism of S1P on human resistance arterioles was investigated. We hypothesized that S1P induces NO-mediated vasodilation in human arterioles from adults without coronary artery disease (non-coronary artery disease) through activation of 2 receptors, S1PR₁ (S1P receptor 1) and S1PR₃ (S1P receptor 3). Furthermore, we tested whether this mechanism is altered in vessels from patients diagnosed with coronary artery disease.

Methods

Human arterioles (50-200 µm in luminal diameter) were dissected from otherwise discarded su

SUBMITTER: Katunaric B 

PROVIDER: S-EPMC9473289 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature