The combination of DNA methylome and transcriptome revealed the intergenerational inheritance on the influence of advanced maternal age.

ABSTRACT:

Background

The number of women delivering at advanced maternal age (AMA; > = 35) continuously increases in developed and high-income countries. Large cohort studies have associated AMA with increased risks of various pregnancy complications and adverse pregnancy outcomes, which raises great concerns about the adverse effect of AMA on the long-term health of offspring. Specific acquired characteristics of parents can be passed on to descendants through certain molecular mechanisms, yet the underlying connection between AMA-related alterations in parents and that in offspring remains largely uncharted.

Methods

We profiled the DNA methylomes of paired parental peripheral bloods and cord bloods from 20 nuclear families, including 10 AMA and 10 Young, and additional transcriptome

SUBMITTER: Hua L 

PROVIDER: S-EPMC9473489 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature