Combinatorial synthesis enables scalable designer detergents for membrane protein studies.

ABSTRACT: Non-ionic detergents with tailor-made properties are indispensable tools for today's world applications, such as cleaning, disinfection, and drug discovery. To facilitate their challenging production, herein we introduce a new detergent class, namely scalable hybrid detergents. We report a combinatorial synthesis strategy that allows us to fuse head groups of different detergents into hybrid detergents with unbeatable ease. Importantly, combinatorial synthesis also enables the choice between (i) high-throughput preparation of detergents for small scale applications and (ii) large scale preparation of individual detergents. This combinatorial synthesis strategy enables an unprecedented fine tuning of detergent properties, such as overall polarity and shape, which are determining factors in

SUBMITTER: Urner LH 

PROVIDER: S-EPMC9473536 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature