Antibiotic-induced depletion of Clostridium species increases the risk of secondary fungal infections in preterm infants.

ABSTRACT: Preterm infants or those with low birth weight are highly susceptible to invasive fungal disease (IFD) and other microbial or viral infection due to immaturity of their immune system. Antibiotics are routinely administered in these vulnerable infants in treatment of sepsis and other infectious diseases, which might cause perturbation of gut microbiome and hence development of IFD. In this study, we compared clinical characteristics of fungal infection after antibiotic treatment in preterm infants. As determined by 16S rRNA sequencing, compared with non-IFD patients with or without antibiotics treatment, Clostridium species in the intestinal tracts of patients with IFD were almost completely eliminated, and Enterococcus were increased. We established a rat model of IFD by intr

SUBMITTER: Huang D 

PROVIDER: S-EPMC9473543 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature