Ontology highlight
ABSTRACT:
SUBMITTER: de Almeida L
PROVIDER: S-EPMC9473568 | biostudies-literature | 2022 Sep
REPOSITORIES: biostudies-literature
de Almeida Letícia L da Silva Alexandre L N ALN Rodrigues Tamara S TS Oliveira Samuel S Ishimoto Adriene Y AY Seribelli Amanda A AA Becerra Amanda A Andrade Warrison A WA Ataide Marco A MA Caetano Camila C S CCS de Sá Keyla S G KSG Pelisson Natália N Martins Ronaldo B RB de Paula Souza Juliano J Arruda Eurico E Batah Sabrina S SS Castro Ricardo R Frantz Fabiani G FG Cunha Fernando Q FQ Cunha Thiago M TM Fabro Alexandre T AT Cunha Larissa D LD Louzada-Junior Paulo P de Oliveira Rene D R RDR Zamboni Dario S DS
Science advances 20220914 37
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) induces mild or asymptomatic COVID-19 in most cases, but some patients develop an excessive inflammatory process that can be fatal. As the NLRP3 inflammasome and additional inflammasomes are implicated in disease aggravation, drug repositioning to target inflammasomes emerges as a strategy to treat COVID-19. Here, we performed a high-throughput screening using a 2560 small-molecule compound library and identified FDA-approved drugs tha ...[more]