Asymmetric multifunctionalization of alkynes via photo-irradiated organocatalysis.

ABSTRACT: Alkynes represent a family of pivotal and sustainable feedstocks for various industries such as pharmaceuticals, agrochemicals, and materials, and they are widely used as important starting materials for the production of a broad range of chemical entities. Nevertheless, efficient structural elaborations of alkynes in chemical synthesis, especially asymmetric multifunctionalization of alkynes, remain largely unexplored. It is thus imperative to develop new asymmetric synthetic approaches, making use of these richly available chemical feedstocks, and enabling their conversion to value-added chiral molecules. Here, we disclose our findings on highly enantioselective multifunctionalization of alkynes by merging photochemistry and chiral phosphoric acid catalysis. Our reported one-pot syntheti

SUBMITTER: Dai L 

PROVIDER: S-EPMC9473573 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature