In situ diagnosis and simultaneous treatment of cardiac diseases using a single-device platform.

ABSTRACT: The in situ diagnosis of cardiac activities with simultaneous therapeutic electrical stimulation of the heart is key to preventing cardiac arrhythmia. Here, we present an unconventional single-device platform that enables in situ monitoring even in a wet condition and control of beating heart motions without interferences to the recording signal. This platform consists of the active-matrix array of pressure-sensitive transistors for detecting cardiac beatings, biocompatible, low-impedance electrodes for cardiac stimulations, and an alginate-based hydrogel adhesive for attaching this platform conformally to the epicardium. In contrast to conventional electrophysiological sensing using electrodes, the pressure-sensitive transistors measured mechanophysiological characteristics by monitoring

SUBMITTER: Hwang JC 

PROVIDER: S-EPMC9473581 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature