Ontology highlight
ABSTRACT:
SUBMITTER: Sathanantham P
PROVIDER: S-EPMC9473614 | biostudies-literature | 2022 Sep
REPOSITORIES: biostudies-literature
Sathanantham Preethi P Zhao Wenhao W He Guijuan G Murray Austin A Fenech Emma E Diaz Arturo A Schuldiner Maya M Wang Xiaofeng X
PLoS pathogens 20220901 9
Positive-strand RNA viruses assemble their viral replication complexes (VRCs) on specific host organelle membranes, yet it is unclear how viral replication proteins recognize and what motifs or domains in viral replication proteins determine their destinations. We show here that an amphipathic helix, helix B in replication protein 1a of brome mosaic virus (BMV), is necessary for 1a's localization to the nuclear endoplasmic reticulum (ER) membrane where BMV assembles its VRCs. Helix B is also suf ...[more]