Serotonergic neuron ribosomal proteins regulate the neuroendocrine control of Drosophila development.

ABSTRACT: The regulation of ribosome function is a conserved mechanism of growth control. While studies in single cell systems have defined how ribosomes contribute to cell growth, the mechanisms that link ribosome function to organismal growth are less clear. Here we explore this issue using Drosophila Minutes, a class of heterozygous mutants for ribosomal proteins. These animals exhibit a delay in larval development caused by decreased production of the steroid hormone ecdysone, the main regulator of larval maturation. We found that this developmental delay is not caused by decreases in either global ribosome numbers or translation rates. Instead, we show that they are due in part to loss of Rp function specifically in a subset of serotonin (5-HT) neurons that innervate the prothoracic gland to co

SUBMITTER: Deliu LP 

PROVIDER: S-EPMC9473637 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature