Organocopper(ii) complexes: new catalysts for carbon-carbon bond formation via electrochemical atom transfer radical addition (eATRA).

ABSTRACT: Organocopper(ii) complexes are a rarity while organocopper(i) complexes are commonplace in chemical synthesis. In the course of building a strategy to generate organocopper(ii) species utilizing electrochemistry, a method to form compounds with Cu^II-C bonds was discovered, that demonstrated remarkably potent reactivity towards different functionalized alkenes under catalytic control. The role of the organocopper(ii) complex is to act as a source of masked radicals (in this case ˙CH₂CN) that react with an alkene to generate the corresponding γ-halonitrile in good yields through atom transfer radical addition (ATRA) to various alkenes. The organocopper(ii) complexes can be continuously regenerated electrochemically for ATRA (eATRA), which proceeds at room tempera

SUBMITTER: Gonzalvez MA 

PROVIDER: S-EPMC9473645 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature