A Val⁶⁶Met polymorphism is associated with weaker somatosensory cortical activity in individuals with cerebral palsy.

ABSTRACT:

Background

The brain-derived neurotrophic factor (BDNF) protein plays a prominent role in the capacity for neuroplastic change. However, a single nucleotide polymorphism at codon 66 of the BDNF gene results in significant reductions in neuroplastic change. Potentially, this polymorphism also contributes to the weaker somatosensory cortical activity that has been extensively reported in the neuroimaging literature on cerebral palsy (CP).

Aims

The primary objective of this study was to use magnetoencephalography (MEG) to probe if BDNF genotype affects the strength of the somatosensory-evoked cortical activity seen within individuals with CP.

Methods and procedures

and Procedures: Twenty individuals with CP and eighteen neurotypical controls participated. S

SUBMITTER: Trevarrow M 

PROVIDER: S-EPMC9474307 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature