Single-subject analysis of regional brain volumetric measures can be strongly influenced by the method for head size adjustment.

ABSTRACT:

Purpose

Total intracranial volume (TIV) is often a nuisance covariate in MRI-based brain volumetry. This study compared two TIV adjustment methods with respect to their impact on z-scores in single subject analyses of regional brain volume estimates.

Methods

Brain parenchyma, hippocampus, thalamus, and TIV were segmented in a normal database comprising 5059 T1w images. Regional volume estimates were adjusted for TIV using the residual method or the proportion method. Age was taken into account by regression with both methods. TIV- and age-adjusted regional volumes were transformed to z-scores and then compared between the two adjustment methods. Their impact on the detection of thalamus atrophy was tested in 127 patients with multiple sclerosis.

Results

The residual m

SUBMITTER: Opfer R 

PROVIDER: S-EPMC9474386 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature