Staphylococcus epidermidis WF2R11 Suppresses PM_2.5-Mediated Activation of the Aryl Hydrocarbon Receptor in HaCaT Keratinocytes.

ABSTRACT: The skin supports a diverse microbiome whose imbalance is related to skin inflammation and diseases. Exposure to fine particulate matter (PM_2.5), a major air pollutant, can adversely affect the skin microbiota equilibrium. In this study, the effect and mechanism of PM_2.5 exposure in HaCaT keratinocytes were investigated. PM_2.5 stimulated the aryl hydrocarbon receptor (AhR) to produce reactive oxygen species (ROS) in HaCaT cells, leading to mitochondrial dysfunction and intrinsic mitochondrial apoptosis. We observed that the culture medium derived from a particular skin microbe, Staphylococcus epidermidis WF2R11, remarkably reduced oxidative stress in HaCaT cells caused by PM_2.5-mediated activation of the AhR pathway. Staphylococcus epidermidis WF

SUBMITTER: Lee E 

PROVIDER: S-EPMC9474527 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature