[¹⁸F]FDG-PET/CT radiomics for the identification of genetic clusters in pheochromocytomas and paragangliomas.

ABSTRACT:

Objectives

Based on germline and somatic mutation profiles, pheochromocytomas and paragangliomas (PPGLs) can be classified into different clusters. We investigated the use of [¹⁸F]FDG-PET/CT radiomics, SUV_max and biochemical profile for the identification of the genetic clusters of PPGLs.

Methods

In this single-centre cohort, 40 PPGLs (13 cluster 1, 18 cluster 2, 9 sporadic) were delineated using a 41% adaptive threshold of SUV_peak ([¹⁸F]FDG-PET) and manually (low-dose CT; ldCT). Using PyRadiomics, 211 radiomic features were extracted. Stratified 5-fold cross-validation for the identification of the genetic cluster was performed using multinomial logistic regression with dimensionality reduction incorporated per fold. Classificatio

SUBMITTER: Noortman WA 

PROVIDER: S-EPMC9474528 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature