Liver regeneration after partial hepatectomy is improved in the absence of aryl hydrocarbon receptor.

ABSTRACT: The liver is among the few organs having the ability to self-regenerate in response to a severe damage compromising its functionality. The Aryl hydrocarbon receptor (Ahr) is a transcription factor relevant for the detoxification of xenobiotics but also largely important for liver development and homeostasis. Hence, liver cell differentiation is developmentally modulated by Ahr through the controlled expression of pluripotency and stemness-inducing genes. Here, 2/3 partial hepatectomy (PH) was used as a clinically relevant approach to induce liver regeneration in Ahr-expressing (Ahr^+/+) and Ahr-null (Ahr^-/-) mice. Ahr expression and activity were early induced after 2/3 PH to be gradually downmodulated latter during regeneration. Ahr^-/- mice triggered liver

SUBMITTER: Rejano-Gordillo CM 

PROVIDER: S-EPMC9474532 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature