Exosome based analysis for Space Associated Neuro-Ocular Syndrome and health risks in space exploration.

ABSTRACT: Molecular profiling to characterize the effects of environmental exposures is important from the human health and performance as well as the occupational medicine perspective in space exploration. We have developed a novel exosome-based platform that allows profiling of biological processes in the body from a variety of body fluids. The technology is suitable for diagnostic applications as well as studying the pathophysiology of the Space Associated Neuro-Ocular Syndrome in astronauts and monitoring patients with chronically impaired cerebrospinal fluid drainage or elevated intracranial pressure. In this proof-of-concept, we demonstrate that: (a) exosomes from different biofluids contain a specific population of RNA transcripts; (b) urine collection hardware aboard the ISS is compatible wi

SUBMITTER: Chakrabortty SK 

PROVIDER: S-EPMC9474550 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature