The potential of hyperpolarised ¹³C-MRI to target glycolytic tumour core in prostate cancer.

ABSTRACT: Hyperpolarised [1-¹³C]pyruvate MRI (HP-¹³C-MRI) is an emerging metabolic imaging technique that has shown promise for evaluating prostate cancer (PCa) aggressiveness. Accurate tumour delineation on HP-¹³C-MRI is vital for quantitative assessment of the underlying tissue metabolism. However, there is no consensus on the optimum method for segmenting HP-¹³C-MRI, and whole-mount pathology (WMP) as the histopathological gold-standard is only available for surgical patients. Although proton MRI can be used for tumour delineation, this approach significantly underestimates tumour volume, and metabolic tumour segmentation based on HP-¹³C-MRI could provide an important functional metric of tumour volume. In this study, we quantified metabolism

SUBMITTER: Sushentsev N 

PROVIDER: S-EPMC9474577 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature