Regulation of Gene Expression Through Effector-dependent Conformational Switching by Cobalamin Riboswitches.

ABSTRACT: Riboswitches are an outstanding example of genetic regulation mediated by RNA conformational switching. In these non-coding RNA elements, the occupancy status of a ligand-binding domain governs the mRNA's decision to form one of two mutually exclusive structures in the downstream expression platform. Temporal constraints upon the function of many riboswitches, requiring folding of complex architectures and conformational switching in a limited co-transcriptional timeframe, make them ideal model systems for studying these processes. In this review, we focus on the mechanism of ligand-directed conformational changes in one of the most widely distributed riboswitches in bacteria: the cobalamin family. We describe the architectural features of cobalamin riboswitches whose structures have been

SUBMITTER: Lennon SR 

PROVIDER: S-EPMC9474592 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature