Changing paradigms in oncology: Toward noncytotoxic treatments for advanced gliomas.

ABSTRACT: Glial-lineage malignancies (gliomas) recurrently mutate and/or delete the master regulators of apoptosis p53 and/or p16/CDKN2A, undermining apoptosis-intending (cytotoxic) treatments. By contrast to disrupted p53/p16, glioma cells are live-wired with the master transcription factor circuits that specify and drive glial lineage fates: these transcription factors activate early-glial and replication programs as expected, but fail in their other usual function of forcing onward glial lineage-maturation-late-glial genes have constitutively "closed" chromatin requiring chromatin-remodeling for activation-glioma-genesis disrupts several epigenetic components needed to perform this work, and simultaneously amplifies repressing epigenetic machinery instead. Pharmacologic inhibition of repressing e

SUBMITTER: von Knebel Doeberitz N 

PROVIDER: S-EPMC9474618 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature