Development and validation of a life expectancy calculator for US patients with prostate cancer.

ABSTRACT:

Objective

To develop and validate an accurate, usable prediction model for other-cause mortality (OCM) in patients with prostate cancer diagnosed in the United States.

Materials and methods

Model training was performed using the National Health and Nutrition Examination Survey 1999-2010 including men aged >40 years with follow-up to the year 2014. The model was validated in the Prostate, Lung, Colon, and Ovarian Cancer Screening Trial prostate cancer cohort, which enrolled patients between 1993 and 2001 with follow-up to the year 2015. Time-dependent area under the curve (AUC) and calibration were assessed in the validation cohort. Analyses were performed to assess algorithmic bias.

Results

The 2420 patient training cohort had 459 deaths over a median follow-up of 8.8

SUBMITTER: Chase EC 

PROVIDER: S-EPMC9474626 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature