Genetic testing to guide screening for pancreatic ductal adenocarcinoma: Results of a microsimulation model.

ABSTRACT:

Background

First-degree relatives (FDRs) of patients with pancreatic ductal adenocarcinoma (PDAC) have elevated PDAC risk, partially due to germline genetic variants. We evaluated the potential effectiveness of genetic testing to target MRI-based screening among FDRs.

Methods

We used a microsimulation model of PDAC, calibrated to Surveillance, Epidemiology, and End Results (SEER) data, to estimate the potential life expectancy (LE) gain of screening for each of the following groups of FDRs: individuals who test positive for each of eight variants associated with elevated PDAC risk (e.g., BRCA2, CDKN2A); individuals who test negative; and individuals who do not test. Screening was assumed to take place if LE gains were achievable. We simulated multiple screening approaches, d

SUBMITTER: Peters MLB 

PROVIDER: S-EPMC9474673 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature