Effects of Light-absorbing Carbons in Intraoperative Molecular Imaging-Guided Lung Cancer Resections.

ABSTRACT:

Background

One of the novel advancements to enhance the visual aspects of lung cancer identification is intraoperative molecular imaging (IMI), which can reliably detect tumors that would otherwise be missed by standard techniques such as tactile and visual feedback, particularly for sub-centimeter or ground-glass nodules. However, there remains a subset of patients who do not benefit from IMI due to excessive background fluorescence secondary to parenchymal light-absorbing carbon deposition. Our goal was to identify the effects of these carbonaceous materials on the quality of IMI-guided lung cancer resections.

Study design and methods

Between July 2014 and May 2021, a total of 311 patients were included in the study. Patients underwent infusion of the study drug OTL38 or I

SUBMITTER: Azari F 

PROVIDER: S-EPMC9474735 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature