Ontology highlight
ABSTRACT:
SUBMITTER: Fan X
PROVIDER: S-EPMC9474879 | biostudies-literature | 2022 Sep
REPOSITORIES: biostudies-literature
Fan Xuejun X Yuan Zihao Z Zhao Yueshui Y Xiong Wei W Hsiao Hao-Ching HC Pare Rahmawati R Ding Jianmin J Almosa Ahmad A Sun Kai K Zhang Songlin S Jordan Robert E RE Lee Cheok Song CS An Zhiqiang Z Zhang Ningyan N
Communications biology 20220914 1
Natural killer (NK) cells mediate antibody dependent cytotoxic killing of cancer cells via cross-linking FcγR on NK cells with IgG-Fc. Studies have shown that the single-hinge cleaved IgGs (scIgGs) have dysfunctional Fc and failed engagement with FcγRs on immune cells. However, little is known about how scIgGs impact on antitumor immunity in the tumor microenvironment. In this study, we revealed a significant association of tumor scIgGs with tumor progression and poor outcomes of breast cancer p ...[more]