Night blood pressure variability, brain atrophy, and cognitive decline.

ABSTRACT:

Background

Although blood pressure variability (BPV) has emerged as a novel risk factor for Alzheimer's disease, few studies have examined the effects of night BPV on brain structure and function. This study investigated the association of night BPV with brain atrophy and cognitive function changes.

Methods

The analysis included 1,398 participants with valid ambulatory blood pressure (BP) monitoring at baseline and both baseline and 4-year follow-up brain magnetic resonance images who were recruited from the Korean Genome and Epidemiology Study. Participants underwent a comprehensive neuropsychological test battery. BPV was derived from ambulatory BP monitoring and calculated as a standard deviation (SD) of 24-h and daytime and nighttime BP.

Results

During the median

SUBMITTER: Yu JH 

PROVIDER: S-EPMC9474888 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature