Synergistic antioxidant effects of natural compounds on H₂O₂-induced cytotoxicity of human monocytes.

ABSTRACT: Natural compounds are endowed with a broad spectrum of biological activities, including protection against Toxins. Most of them are known for their antioxidant and radical scavenging activities. However, the synergistic combination of these natural molecules is not well studied. Therefore, the present study aims first to investigate the effect of four potent natural molecules [rosmarinic acid (Ros-A), ellagic acid (Ella-A), curcumin (Cur), and syringic acid (Syr-A)] on H₂O₂ -induced cell cytotoxicity and oxidative stress on the human monocytes (THP-1) and then to evaluate their combined action effect. Optimal combinations of these molecules were predicted using an augmented mixture design approach. In the first, as preliminary antioxidant activities screening, two

SUBMITTER: Ben Mrid R 

PROVIDER: S-EPMC9474927 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature