Quercetin targets VCAM1 to prevent diabetic cerebrovascular endothelial cell injury.

ABSTRACT:

Introduction

Endothelial cells play important roles in neurodegenerative diseases caused by diabetes, therefore, we aimed at investigating the mechanisms through which endothelial cells are involved in diabetes development.

Methods

Single cell analysis was performed to identify the major endothelial cell subtypes in cardiovascular tissues that are involved in diabetes development. A cell-cell communication approach was then used to identify ligand-receptor interaction pairs between these cell types. Differential expression analysis between the two experimental groups [standard chow diet group and diabetogenic diet with cholesterol (DDC) group] was used to identify diabetes-related differentially expressed genes (DEGs). The upregulated genes were used to identify candidate li

SUBMITTER: Huang J 

PROVIDER: S-EPMC9475220 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature