Association of longitudinal repeated measurements of frailty index with mortality: Cohort study among community-dwelling older adults.

ABSTRACT:

Background

Frailty indices (FIs), defined by accumulation of health deficits, have been shown to be strongly related to mortality in older adults. However, previous studies mostly relied on FI measurement at a single point of time. We aimed to investigate the association of frailty with mortality according to longitudinal repeated measurements of FI in a large population-based cohort study in Germany.

Methods

Among 9912 men and women aged 50-75 years living in Saarland, Germany and recruited in the ESTHER study in 2000-2002, a FI based on 30 deficits was determined at baseline, 2-, 5-, 8-, and 11-year follow-up. Hazard ratios (HRs) were calculated to assess the associations of FI with all-cause mortality and cause-specific mortality during 14 years of follow-up using Cox pro

SUBMITTER: Li X 

PROVIDER: S-EPMC9475257 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature