Immune characterization of suicidal behavior in female adolescents.

ABSTRACT:

Background

To address the need to identify potential markers of suicide behavior for adolescents (ages 12-18 years), mass cytometry was used to explore the cellular mechanisms that may underpin immune dysregulation in adolescents with recent suicidal behavior.

Methods

Peripheral blood mononuclear cell (PBMC) samples from 10 female adolescents with a recent suicide attempt and 4 healthy female adolescents were used. A panel of 30 antibodies was analyzed using mass cytometry. We used two complementary approaches to 1) identify the cell types that significantly differed between the two groups, and 2) explore differences in the expression profile of markers on the surface of these cells. Mass cytometry data were investigated using (Center for Disease Control, 2021) Opt-SNE for d

SUBMITTER: Chin Fatt CR 

PROVIDER: S-EPMC9475263 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature